Stoped my fuzzing experience when appeared the pointlessness-for my concern- of this activity...
Due to the vulnerability assessmentt business (Idefense, Vupen, Immunitysec etc.), we can not expect effective tools by one click download to our hands...
TaintScope, wich seems very interesting is currently not public, and i guess that it is not due to vulnerability/software assessment market (Red CyberArmy ? ).
Still a few tools like theses ones, that might disappoint some people
zzuf
http://caca.zoy.org/wiki/zzuf
fuzzgrind
http://esec-lab.sogeti.com/pages/Fuzzgrind
Flayer and Avalache related to the well known Valgrind framework
http://code.google.com/p/flayer/
http://code.google.com/p/avalanche/
rgds