We've successfully patched hardened VirtualBox starting from build 95226, up to 95286 (and inc.latest svn build with "advanced unhooking" crap they implemented) without any binary modifications on disk and with NO reaction from their crapware protection. Details will be posted later, with official release as we still have to re-check all things are OK in case if Oracle drugdillers deliver more cocaine to VBox dev's.
Ring0 - the source of inspiration